An Inside Look at Hippocampal Silent Cells
نویسندگان
چکیده
Hippocampal pyramidal cells can be divided into place cells, which fire action potentials when an animal is in specific locations, and silent cells, which are not spatially selective. In this issue of Neuron, Epsztein et al. find intracellular differences between place and silent cells by using whole-cell recordings in freely moving rats.
منابع مشابه
Place cells and silent cells in the hippocampus of freely-behaving rats.
In the present study, nearly two-thirds of all hippocampal pyramidal units isolated under barbiturate anesthesia, which maximizes these cell's activity, were behaviorally silent. These "silent cells" showed no spontaneous firing activity in the awake, freely-behaving rat. Both reanesthetization and antidromic stimulation, however, activated these silent cells. More than 92% of the remaining spo...
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Recent work has suggested that some proportion of excitatory synapses on hippocampal CA1 pyramidal cells that express NMDA receptors (NMDARs) may not express functional AMPA receptors (AMPARs), thus making these synapses silent at the resting membrane potential. In agreement with this hypothesis, we demonstrate here that it is possible to stimulate synapses that yield no detectable excitatory p...
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ورودعنوان ژورنال:
- Neuron
دوره 70 شماره
صفحات -
تاریخ انتشار 2011